The Axios Valley, located in central-northern Greece, is surrounded by complex topography that plays a significant role in the modification of wind flow, both in terms of speed and direction. The characteristic wind regime of this valley is Vardaris, a northwesterly wind that prevails in this region, especially during the cold period of the year. Vardaris is well known for its consistent direction and high intensity, as well as for the effective advection of cold and dry air, often resulting to significant damages in local infrastructures and agriculture. A field campaign under the name AXIOS took place during the period from November 2007 through May 2008 in order to examine this particular wind flow. The analysis of the in situ observational data, which was funded by the research program THESPIA-KRIPIS, showed that topography plays a key role in intensifying Vardaris, generating gusts that approximated 30ms-1 during the experimental period. The air temperature and humidity fields were also found to be significantly influenced. In addition to the observational study, an intense Vardaris episode was simulated with the Weather Research and Forecasting (WRF) model at high horizontal resolution. Results revealed that the model was able to reproduce the favorable environmental conditions that lead to Vardaris occurrence, providing a useful insight on the physical mechanisms explaining its structure.